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目的:观察克林霉素等加香菊胶囊治疗1型慢性鼻-鼻窦炎的临床疗效及不良反应。方法:选择慢性鼻-鼻窦炎160例,随机分为观察组和对照组各80例。对照组采用口服克拉霉素治疗,每次0.25g,每天2次,2周后改为每天1次,根据病情治疗6～12周;鼻塞较重、脓鼻涕较多、鼻黏膜水肿明显者,用呋麻滴鼻液滴鼻(不超过7天)及雷诺考特喷鼻;鼻窦冠状位CT显示上颌窦有明显积液者,行上颌窦穿刺冲洗治疗后,注入庆大霉素8万U加地塞米松10mg。观察组在对照组基础上,加服香菊胶囊,每次2粒,每天3次,连用2周。随访3个月后评定临床疗效。结果:观察组总有效77例(96.3%),对照组总有效67例(83.8%),两组比较差异非常显著(P<0.01)。两组均未发现明显血常规异常及肝肾功能损害等不良反应。结论:中西医结合治疗慢性鼻-鼻窦炎疗效好,且安全。
Objective: To observe the clinical efficacy and adverse reactions of clindamycin and other drugs in the treatment of chronic rhinosinusitis. Methods: 160 cases of chronic rhinosinusitis were randomly divided into observation group and control group, 80 cases each. The control group with oral clarithromycin treatment, each 0.25g, 2 times a day, 2 weeks later changed to 1 day, according to the disease treatment of 6 to 12 weeks; severe nasal congestion, purulent nasal discharge, nasal mucosal edema significantly, Nasal drip with furosemide nasal drops (less than 7 days) and Renault test nasal spray; sinus coronal CT showed significant effusion of the maxillary sinus, line maxillary sinus puncture flushing treatment, the injection of gentamicin 80000 U Add dexamethasone 10mg. On the basis of the control group, the observation group added Xiangju capsules twice a day for 3 times daily for 2 weeks. Follow-up 3 months after the assessment of clinical efficacy. Results: The total effective rate was 77 (96.3%) in the observation group and 67 (83.8%) in the control group, with significant difference between the two groups (P <0.01). No significant abnormal blood group and liver and kidney dysfunction were found in both groups. Conclusion: Integrative Chinese medicine treatment of chronic rhinosinusitis effective, safe.