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于小鼠阴道内多次接种HSV-2,半年后诱癌率为22.6％,加巴豆油反复涂抹后,诱癌率升高到63.33％;而对照组(包括未用病毒和巴豆油处理组、仅用巴豆油处理组)未发现癌。加用巴豆油组5个月取材的诱癌率为42％,与6个月的诱癌率比较,二者差异有显著性。以间接免疫荧光法测得患癌小鼠HSV-2抗体水平升高。提示:HSV-2感染以后,促癌剂能大大增加发癌危险;实验持续6个月的诱癌率高于5个月的诱癌率。
HSV-2 was inoculated several times in the vagina of mice, the rate of induced cancer was 22.6% after six months, and the cancer-inducing rate increased to 63.33% after repeated application of croton oil, while the control group (including virus-free and croton oil- , Only croton oil treatment group) found no cancer. The addition of croton oil group of 5-month drawn cancer induction rate was 42%, and 6-month cancer induction rate, the difference was significant. The level of HSV-2 antibody in cancer-bearing mice was measured by indirect immunofluorescence. Prompt: After HSV-2 infection, the promotion of cancer agents can greatly increase the risk of cancer; experimental 6-month cancer induction rate is higher than the 5-month cancer induction rate.