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探讨山茱萸总苷抗类风湿关节炎的作用机理。采用改良的Boyden小室前导法检测CⅡ诱导的关节炎大鼠山茱萸总苷治疗组和模型组的原代滑膜细胞培养上清对关节浸润炎性细胞如中性粒细胞、骨髓巨噬细胞和淋巴细胞趋化能力,结果以实验组穿膜细胞数减去对照组穿膜细胞数表示。结果发现:山茱萸总苷治疗组的原代滑膜细胞培养上清对上述三种炎性细胞的趋化能力（穿膜细胞数）均显著低于模型组（P<0.01）。说明山茱萸总苷抑制关节滑膜细胞对炎性细胞的趋化,减少炎性细胞向关节滑膜的浸润是其抗关节炎作用的机理之一。
To explore the mechanism of action of total glucosides of Hawthorn against rheumatoid arthritis. Detection of CII-Induced Arthritis in Rats with Cd-induced Arthritis Using a Modified Boyden Chamber Precursor and Model-Group Primary Synovial Cell Culture Supernatants for Invasion of Joint Inflammatory Cells such as Neutrophils, Bone Marrow Macrophages, and Lymph The cell chemotaxis capacity was expressed as the number of membrane cells in the experimental group minus the number of membrane cells in the control group. The results showed that the chemotaxis of the primary synovial cell culture supernatant of the total glucosides of hawthorn group was significantly lower than that of the model group (P<0.01). It was demonstrated that total glucosides of hawthorn inhibited the chemotaxis of inflammatory cells in synovial cells of the synovium, and the infiltration of inflammatory cells into synovial membranes was one of the mechanisms of its anti-arthritis effects.