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目的探讨骨水泥作为多柔比星缓释载体在经皮椎体后凸成形术(PKP)治疗脊柱肿瘤中的应用价值。方法选择在2013年1月~2014年9月收治的多发性骨髓瘤和脊柱转移瘤患者16例,所有患者均行CR或MRI检查均显示脊椎溶骨性破坏。以骨水泥作为多柔比星缓释载体行PKP治疗,共16例次,20个椎体,包括:胸椎6个,腰椎14个;16例患者均同时取活检。术后行X线片检查,并结合放疗、化疗等治疗。随访3个月,对椎体功能评分、NRS评分进比较。结果以患者术前、术后48h、1个月、2个月、3个月为随访节点,患者术后各个随访节点椎体功能评分、NRS评分均有统计学意义(P<0.05)。结论骨水泥作为多柔比星缓释载体行PKP治疗脊柱肿瘤能即刻缓解疼痛,使脊柱的活动状况改善,术后配合放疗及化疗等治疗措施,临床效果显著。
Objective To investigate the value of bone cement as a sustained release carrier of doxorubicin in the treatment of spinal tumors by percutaneous kyphoplasty (PKP). Methods From January 2013 to September 2014, 16 patients with multiple myeloma and spinal metastases were selected. All patients underwent CR or MRI examination showing osteolytic destruction of the spine. With cement as the doxorubicin sustained-release carrier PKP treatment, a total of 16 cases, 20 vertebral bodies, including: 6 thoracic vertebrae, 14 lumbar vertebrae; 16 patients were simultaneously biopsy. Postoperative X-ray examination, combined with radiotherapy, chemotherapy and other treatment. Follow-up 3 months, vertebral body function score, NRS score into more. Results The patients were followed up 48h, 1 month, 2 months and 3 months after operation. The vertebral body function score and NRS score of each follow-up node were statistically significant (P <0.05). Conclusion PKC as a doxorubicin sustained-release carrier for the treatment of spinal tumors can relieve pain immediately, improve the activity of the spine, and cooperate with radiotherapy and chemotherapy. The clinical effect is obvious.