论文部分内容阅读
肾上腺素是人体内的重要激素,为单胺类物质属儿茶酚胺系列.肾上腺素的生物合成中间产物多巴胺是脑神经递质,它们都具有很强的生理活性.七十年代以来,神经递质的在体(in vivo)电化学测定已有大量研究,而有关电化学氧化机理的研究报导却不多.对该类物质的电化学氧化机理进行研究,不仅有助于其在体电化学测定研究,也有助于揭示它在生理条件下的氧化机制.我们曾对肾上腺素在硫酸介质中,玻碳电极上的循环伏安特性进行过研究.结果表明,其循环伏安谱仅呈现出一对氧化-还原峰(E_(1/2):0.146mV);氧化峰和还原峰的谱形较为尖锐、对称性亦较强;其蜂电流与电势扫描速度v 成正比,而不是扩散物质的能斯特波中所表现出的那种v~(1/2)关系,即其谱图具有法拉第吸附/脱附的特征.在此基础上,本文对肾上腺素在该体系中的交流阻抗特性进行了研究,测得有关电极过程的一些动力学参数,初步推断了其电化学氧化的反应机理。
Epinephrine is an important hormone in the human body, is a series of catecholamine monoamine substances.Adrenergic biosynthesis of dopamine is a brain neurotransmitter, they have a strong physiological activity.Since the seventies, neurotransmitters There are a lot of studies on in vivo electrochemical determination, but there are not many reports on the electrochemical oxidation mechanism.It is not only helpful to study the electrochemical oxidation mechanism of these materials, , But also help to reveal its oxidative mechanism under physiological conditions.We have studied the cyclic voltammetry of epinephrine in sulfuric acid medium and glassy carbon electrode.The results show that the cyclic voltammetry only shows a pair of Oxidation-reduction peak (E_ (1/2): 0.146mV). The oxidation peak and the reduction peak are sharp and symmetrical. The bee current is proportional to the potential scanning velocity v, not to the energy of the diffusion material Stewart waves show the kind of v ~ (1/2) relationship, that is, the spectrum has Faraday adsorption / desorption characteristics .On the basis of this article on the epinephrine in the system AC impedance characteristics Study, measured about the electrode process Some kinetic parameters, we concluded that the reaction mechanism of electrochemical oxidation.