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AIM:To determine the association between seroprevalenceof Helicobacter pylori(H pylori)infection and primary biliarycirrhosis(PBC).METHODS:In this case-control study,149 consecutivepatients(10 males,139 females,mean age 58.2±11 years,range 26-82 years)suffering from PBC and 619 consecutivehealthy volunteer blood donors(523 males,96 females,mean age 47±5.3 years,range 18-65 years)attending theHospital Blood Bank and residing in the same area wererecruited.A commercial enzyme linked immunosorbentassay was used to detect anti-H pylori(IgG)antibodies inserum.RESULTS:AnUbodies to Hpyloriwere present in 78(52.3%)out of 149 PBC-patients and in 291(47%)out of 619volunteers(P=0.24,OR 1.24,95% CI 0.85-1.80).In thesubjects less than 60 years old,the prevalence of H pyloriinfection among PBC-patients(40/79)was slightly higherthan in controls(50.6% vs 46.2%)P=0.46,OR=1.19,95%CI:0.72-1.95).In those over 60 years,the prevalence ofHpylori infection was similar between PBC-patients andcontrols(54.2% vs57.8%,P=0.7,OR 0.86,95% CI 0.36-2.07).CONCLUSION:There is no association between seroprevalenceof H pylori in fection and primary biliary cirrhosis.Durazzo M,Rosina F,Premoli A,Morello E,Fagoonee S,InnarellaR,Solerio E,Pellicano R,Rizzetto M.Lack of association betweenseroprevalence of Helicobacter pylori in fection and primary biliarycirrhosis.World J Gastroenterol 2004;10(21):3179-3181http://www.wjgnet.com/1007-9327/10/3179.asp
AIM: To determine the association between seroprevalence of Helicobacter pylori (H pylori) infection and primary biliarycirrhosis (PBC) .METHODS: In this case-control study, 149 consecutivepatients (10 males, 139 females, mean age 58.2 ± 11 years, range 26- 82 years) suffering from PBC and 619 consecutivehealthy volunteer blood donors (523 males, 96 females, mean age 47 ± 5.3 years, range 18-65 years) attending theHospital Blood Bank and residing in the same area wererecruited. A commercial enzyme linked immunosorbentassay was Out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P = 0.24, OR 1.24, 95 % CI 0.85-1.80) .In the subjects less than 60 years old, the prevalence of Hpylori infection among PBC-patients (40/79) was slightly higherthan in controls (50.6% vs. 46.2%) P = 0.46, OR = 1.19, 95 % CI: 0.72-1.95). Where those over 60 years, the prevalence ofHpylori infection were similar between PBC-patients and controls (54.2% vs 57.8%, P = 0.7, OR 0.86, 95% CI 0.36-2.07) .CONCLUSION: There is no association between seroprevalence of H pylori in fection and primary biliary cirrhosis. Durazzo M, Rosina F, Premoli A, Morello E, Fagoonee S, Innarella R, Solerio E, Pellicano R, Rizzetto M. Lack of association between seroprevalence of Helicobacter pylori in fection and primary biliary cirrhosis. World J Gastroenterol 2004; 10 (21): 3179-3181 http: //www.wjgnet.com/1007- 9327/10 / 3179.asp