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目的 观察 2种剂量的米索前列醇阴道用药的引产效果。方法 选择有引产指征 ,无米索前列醇使用禁忌证的晚期妊娠孕妇 12 6例 ,随机分为A组、B组各 6 3例 ,分别阴道后穹隆放置米索前列醇 2 5 μg 次及 5 0 μg 次 ,间隔 3～ 6h重复给药 ,总量 2 0 0 μg d。胎膜破裂或临产则停止用药。 结果 引产成功率A组 79.4% (5 0 6 3) ,B组 77.8% (4 9 6 3) ,2组比较差异无显著性。宫缩过强发生率、痉挛性宫缩发生率、胎心率不正常发生率A组为6 .35 %、1.6 %、12 .7% ,B组为 2 0 .6 %、12 .7%、2 8.6 % ,2组比较均有显著性差异 (P <0 .0 5 )。结论 小剂量米索前列醇 (2 5 μg 次 )用于晚期妊娠引产同样安全有效 ,且宫缩过强发生率、痉挛性宫缩发生率及胎心不正常发生率较低
Objective To observe the induction effects of two doses of misoprostol for vaginal administration. Methods A total of 126 advanced pregnant women without indications of induction of induction of misoprostol were enrolled in this study. They were randomly divided into group A and group B, with 63 cases in each. Bilateral misoprostol 25 μg and vaginal posterior fornix 5 0 μg times, interval 3 ~ 6 h repeated administration, a total of 200 μg d. Membrane rupture or abortion is to stop medication. Results The success rate of induction of labor in group A was 79.4% (566), in group B 77.8% (4963), there was no significant difference between two groups. The incidence of contractions too strong, the incidence of spastic uterine contractions, abnormal fetal heart rate was 6 .35%, 1.6%, 12.7% in group A, 20.6%, 12.7% in group B , 2 8.6%. There were significant differences between the two groups (P <0.05). Conclusions A small dose of misoprostol (25 μg times) is also safe and effective for induction of labor during late pregnancy, with a low incidence of tocolytic syndrome, spastic tocorrhea and abnormal fetal heart rate