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近年来,随着胎盘免疫学、胎盘病理学的发展,人们逐渐认识到胎盘的免疫保护是妊娠得以建立和维持的机制之一,这种机制的形成是以胎盘滋养细胞的正常发育为基础[1]。正常早孕绒毛滋养细胞迅速增生,并分化为内外两层,其中内层的细胞滋养细胞分裂活跃,核内DNA合成旺盛[2]。与此同时,部分滋养细胞发生凋亡。增殖和凋亡活性的对比,决定了滋养细胞的生存活性。细胞增殖活性降低或细胞凋亡能力增强,可能导致自然流产;而细胞增殖活性增强或
In recent years, with placental immunology, the development of placental pathology, people gradually come to realize that the immune protection of the placenta is one of the mechanisms of pregnancy to establish and maintain the formation of this mechanism is based on the normal development of placental trophoblast cells [ 1]. Normal early pregnancy villous trophoblast cells proliferate rapidly and differentiate into two layers inside and outside, in which the inner cytotrophoblast cell division active nuclear DNA synthesis exuberant [2]. At the same time, some of the trophoblastic cells apoptosis. A comparison of proliferative and apoptotic activities determines the viability of trophoblasts. Decreased cell proliferation activity or increased apoptosis, may lead to spontaneous abortion; and cell proliferation activity increased or