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目的:探讨卵泡液中双酚A(bisphenol A,BPA)在多囊卵巢综合征(PCOS)发病中的作用。方法:于取卵日收集行体外受精/卵胞质内单精子显微注射(IVF/ICSI)的PCOS患者和非PCOS患者的卵泡液,检测患者卵泡液BPA水平和卵泡液性激素水平,并进一步与患者血清抗苗勒氏管激素(AMH)及临床结局等因素行相关性分析。结果:PCOS患者和非PCOS患者的卵泡液BPA水平(446.57±63.57 ng/L vs 336.29±59.02 ng/L,P<0.001)、血清AMH水平(12.09±4.78μg/L vs5.69±2.98μg/L,P<0.001)、卵泡液FSH(5.58±1.66 IU/L vs 3.95±1.54 IU/L,P=0.008)、LH(4.54±2.97 IU/L vs 0.96±1.10 IU/L,P<0.001)和T(54.68±34.34 nmol/L vs 32.48±16.68 nmol/L,P=0.035)组间比较有统计学差异。相关性分析显示,卵泡液中BPA水平与血清AMH水平呈显著正相关(r=0.577,P=0.001)。结论:卵巢局部的BPA暴露可能参与了PCOS疾病的发生、发展。
Objective: To investigate the role of bisphenol A (BPA) in follicular fluid in the pathogenesis of polycystic ovary syndrome (PCOS). Methods: Follicular fluid of PCOS patients and non-PCOS patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI) were collected on the day of ovulation. The follicular fluid BPA level and follicular fluid sex hormone level were measured and compared with Correlation analysis of serum anti-Müllerian hormone (AMH) and clinical outcome among patients. Results: The levels of BPA in follicular fluid of PCOS patients and non-PCOS patients (446.57 ± 63.57 ng / L vs 336.29 ± 59.02 ng / L, P <0.001), serum AMH levels (12.09 ± 4.78 μg / L vs 5.69 ± 2.98 μg / L, P <0.001), follicular fluid FSH (5.58 ± 1.66 IU / L vs 3.95 ± 1.54 IU / L, P = 0.008) and LH (4.54 ± 2.97 IU / L vs 0.96 ± 1.10 IU / L, P <0.001) And T (54.68 ± 34.34 nmol / L vs 32.48 ± 16.68 nmol / L, P = 0.035). Correlation analysis showed that follicular fluid BPA levels and serum AMH levels were significantly correlated (r = 0.577, P = 0.001). Conclusion: BPA exposure in ovary may be involved in the occurrence and development of PCOS.