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ACNU〔1-(4-amino-2-methyl-5-pyrimidinyl)-3(2-chloro ethyl)3nitrosourea hydrochloride〕是新型抗癌剂,作者对6例再发性脑肿瘤经导管注入A CNU,成人用量为100mg,小儿为50mg,溶于30ml生理盐水中,用自动注射器在15分钟注入。所有病例均依Seldinger法经股动脉插管,肿瘤位于颈内动脉区域时,将微导管(2.5F)前端留置于眼动脉分枝部远端。病例1、2、5尽量将导管插至大脑中动脉起始部,以使肿瘤部位能达较高药剂浓度,病例2、5、6应用了标定漏口球囊导管,病例3导管(7 F)置于颈内动脉起始部,病例2、4肿瘤有
ACNU 〔1- (4-amino-2-methyl-5-pyrimidinyl) -3 (2-chloroethyl) 3 nitrosourea hydrochloride〕 is a new anticancer agent, the authors of 6 cases of recurrent brain tumors by catheter into CNU, adult The dosage is 100mg, pediatric is 50mg, dissolved in 30ml saline, injected with an auto-injector in 15 minutes. All patients were intubated via the femoral artery according to Seldinger’s method. When the tumor was located in the internal carotid artery, the tip of microcatheter (2.5F) was placed in the distal part of the branch of the ophthalmic artery. Case 1, 2, 5 as far as possible the catheter inserted in the beginning of the middle cerebral artery, so that the tumor site can reach a higher concentration of drugs, cases 2,5,6 using a calibrated leaky balloon catheter, Case 3 catheter (7 F ) Placed in the beginning of the internal carotid artery, cases 2 and 4 tumors