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目的 探讨多发性硬化（ＭＳ）患者外周血白细胞糖皮质激素受体（ＧＲ）含量与糖皮质激素的治疗效果关系。方法用放射免疫法和放射配体结合法测定２５例ＭＳ患者的血浆皮质醇（Ｆ）含量和血白细胞ＧＲ含量。结果ＭＳ患者血浆Ｆ含量与正常对照组无明显差异，而血ＧＲ含量为（８６３５±１４３２）位点／细胞，明显高于正常对照组（５３２０±５４０）位点／细胞（Ｐ＜０．０１）。用常规大剂量激素治疗时，治疗前ＧＲ位点数高者［（９３５６±６４５）位点／细胞共１８例］，疗效优于位点数低者［（６１７６±３８５）７例］。结论ＭＳ患者外周血白细胞ＧＲ增多，ＧＲ含量高者近期疗效较好，ＧＲ含量低者可加用超大剂量激素治疗，以提高疗效。
Objective To investigate the relationship between glucocorticoid receptor (GR) levels in peripheral blood leukocytes and the therapeutic effect of glucocorticoids in patients with multiple sclerosis (MS). Methods The levels of plasma cortisol (F) and white blood cell (GR) in 25 MS patients were determined by radioimmunoassay and radioligand binding assay. Results There was no significant difference in plasma F content between MS patients and normal controls, but the level of blood GR was (8635 ± 1432) / cell, significantly higher than that of normal control group (5320 ± 540) (P <0.01 ). With conventional high-dose hormone therapy, the highest number of GR sites before treatment [(9356 ± 645) sites / cells in 18 cases], the effect is better than the low number of sites [(6176 ± 385) 7 cases]. Conclusions MS patients with peripheral blood leukocytes increased GR, GR content of the recent better curative effect, low GR content may be added with large doses of hormone therapy to improve the curative effect.