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目的探讨TGF-β与IL-6在老年2型糖尿病伴甲状腺功能亢进患者的表达及临床意义。方法 40例2型糖尿病伴甲状腺功能亢进的老年患者为实验组,另选取体检中心同期体检正常人群40例为对照组。观察两组TGF-β与IL-6的水平差异;检查并记录两组甲状腺激素、血糖、血脂及血压情况。结果实验组TGF-β与IL-6水平高于对照组(P<0.05);实验组甲状腺激素和血糖水平高于对照组(P<0.05);两组血脂、血压水平差异无统计学意义(P>0.05)。结论 TGF-β与IL-6水平在老年2型糖尿病伴甲状腺功能亢进患者的表达呈正相关,TGF-β与IL-6可能参与老年2型糖尿病伴甲亢疾病的发生发展。临床应加大对两种症状合并时的认识,完善两种疾病的兼顾治疗。
Objective To investigate the expression and clinical significance of TGF-β and IL-6 in elderly type 2 diabetic patients with hyperthyroidism. Methods Forty elderly patients with type 2 diabetes mellitus and hyperthyroidism were selected as the experimental group and 40 healthy subjects at the same time as the control group. The levels of TGF-β and IL-6 in the two groups were observed. Thyroid hormone, blood glucose, blood lipid and blood pressure were examined and recorded. Results The levels of TGF-β and IL-6 in the experimental group were significantly higher than those in the control group (P <0.05). The levels of thyroid hormones and blood glucose in the experimental group were higher than those in the control group (P <0.05). There was no significant difference in the levels of serum lipids and blood pressure between the two groups P> 0.05). Conclusion The expression of TGF-β and IL-6 in elderly type 2 diabetes mellitus patients with hyperthyroidism is positively correlated. TGF-β and IL-6 may be involved in the development of type 2 diabetes mellitus with hyperthyroidism. Clinics should increase awareness of the merger of the two symptoms, improve the treatment of both diseases.