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目的:研究基质金属蛋白酶-2、9(MMP-2、9)与动脉粥样硬化性脑梗死初发及复发的相关性。方法:选取脑梗死初发350例,复发340例,对照组360例。ELISA法检测MMP-2、9的含量,比较三组间MMP-2、9含量的差异。结果:脑梗死初发及复发组血清MMP-2水平显著高于对照组(2.93±0.53mg/L比1.68±0.24mg/L,t=3.156,P<0.05;3.32±0.94mg/L比1.68±0.24mg/L,t=4.053,P<0.05),且复发脑梗死组高于初发脑梗死组(3.32±0.94 mg/L比2.93±0.53 mg/L,t=2.897,P<0.05)。脑梗死初发及复发组血清MMP-9水平均显著高于对照组(1.63±0.53mg/L比0.68±0.24mg/L,t=4.156,P<0.05;1.78±0.94mg/L比0.68±0.24mg/L,t=4.053,P<0.05)。多因素Logistic回归分析结果显示血浆MMP-2水平增高不是发生脑梗死的独立危险因素(OR:0.820,95%CI:0.620~1.058,P>0.05;OR:0.719,95%CI:0.528~1.016,P>0.05)。血浆MMP-9水平增高是脑梗死初发的独立危险因素(OR:1.336,95%CI:1.031~1.072,P=0.028),但不是脑梗死复发的独立危险因素(OR:0.609,95%CI:0.428~1.006,P>0.05)。结论:MMP-2、MMP-9均参与了动脉粥样性硬化性脑梗死初发及复发的发生,MMP-9水平增高是动脉粥样硬化性脑梗死初发的潜在独立危险因素。
AIM: To investigate the relationship between matrix metalloproteinase-2, 9 (MMP-2,9) and initial and recurrence of atherosclerotic cerebral infarction. Methods: 350 cases of initial cerebral infarction, 340 cases of recurrence and 360 cases of control group were selected. The content of MMP-2 and 9 was detected by ELISA, and the difference of MMP-2 and 9 in three groups was compared. Results: The serum levels of MMP-2 in the newly diagnosed and relapsed group were significantly higher than those in the control group (2.93 ± 0.53 mg / L vs 1.68 ± 0.24 mg / L, t = 3.156, P <0.05; 3.32 ± 0.94 mg / L vs 1.68 ± 0.24mg / L, t = 4.053, P <0.05), and the recurrent cerebral infarction group was higher than the initial cerebral infarction group (3.32 ± 0.94 mg / L vs 2.93 ± 0.53 mg / L, t = . The levels of serum MMP-9 in primary and relapse group were significantly higher than those in control group (1.63 ± 0.53mg / L vs 0.68 ± 0.24mg / L, t = 4.156, P <0.05; 1.78 ± 0.94mg / L vs 0.68 ± 0.24 mg / L, t = 4.053, P <0.05). Multivariate Logistic regression analysis showed that elevated plasma MMP-2 level was not an independent risk factor for cerebral infarction (OR: 0.820, 95% CI: 0.620-1.058, P> 0.05; OR: 0.719, 95% CI: 0.528-1.016, P> 0.05). Plasma MMP-9 level was an independent risk factor for initial cerebral infarction (OR: 1.336, 95% CI: 1.031-1.072, P = 0.028), but not an independent risk factor for recurrent cerebral infarction (OR: 0.609, 95% CI : 0.428 ~ 1.006, P> 0.05). Conclusion: Both MMP-2 and MMP-9 are involved in the occurrence and recurrence of atherosclerotic cerebral infarction. Increased MMP-9 level is a potential independent risk factor for initial onset of atherosclerotic cerebral infarction.