论文部分内容阅读
目的探讨恶性血液病患者化疗后粒细胞缺乏期并发侵袭性肺部真菌感染的临床特点及治疗。方法对我院血液科2009年-2012年收治的15例肺部真菌感染患者的临床特征、治疗及预后进行分析。结果 15例患者中,确诊2例,临床诊断9例,拟诊病例4例。11例经抗真菌治疗均有好转。结论侵袭性肺部真菌感染具有临床表现无特异性、进展迅速、死亡率高等特点,经验治疗和抢先治疗是目前最主要的治疗策略。为了进一步减少肺部真菌感染的病死率,建议在高分辨CT的基础上,结合真菌血清免疫学(G/GM试验)检查,以期早期诊断,早期治疗,提高治愈率,减少死亡率。
Objective To investigate the clinical characteristics and treatment of aggressive pulmonary fungal infection in patients with hematologic malignancies after chemotherapy for agranulocytosis. Methods The clinical features, treatment and prognosis of 15 patients with pulmonary fungal infection admitted to our department of hematology from 2009 to 2012 were analyzed. Results Of the 15 patients, 2 were confirmed, 9 were clinically diagnosed, and 4 were diagnosed. 11 cases of anti-fungal treatment have improved. Conclusion Invasive pulmonary fungal infection with non-specific clinical manifestations, rapid progress, high mortality, experience and preemptive treatment is the most important treatment strategy. In order to further reduce the mortality of pulmonary fungal infection, it is recommended to combine high-resolution CT, combined with fungal serum immunology (G / GM test) examination, in order to early diagnosis and early treatment, improve the cure rate and reduce mortality.