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很多实验发现应用内分泌可改变动物淋巴器官的大小和活性。有些学者也主张性激素对体外检测的免疫应答水平有直接影响,至少性激素与胎儿的维持有一定关系,人的天然杀伤细胞(NK)在对病毒、寄生虫和肿瘤的天然宿主抵抗力以及对骨髓的调节中有重要意义。近期在有关乳腺癌的观察中指出性激素调节 NK 效应系统。本文检测了甾类和多肽类激素在体外对 NK 系统的直接效应。实验组包括18名20～40岁的正常志愿者。静脉取血,常规分离单核细胞。用~(51)Cr 标记的对 NK 活性敏感的 K_(562)细胞系与 NK 细胞培养4小时,测上
Many experiments found that the application of endocrine can change the size and activity of animal lymphoid organs. Some scholars have also argued that sex hormones have a direct effect on the level of immune response tested in vitro, with at least a correlation between sex hormones and the maintenance of the fetus, the natural host resistance of human natural killer (NK) cells to viruses, parasites and tumors, The regulation is of great significance. Recent observations in breast cancer indicate that sex hormones regulate the NK effector system. This article examines the direct effects of steroids and peptide hormones on the NK system in vitro. The experimental group includes 18 normal volunteers aged 20 to 40 years. Venous blood, monocytes isolated routine. K (562) cell line which is sensitive to NK activity and labeled with ~ (51) Cr was incubated with NK cells for 4 hours.