论文部分内容阅读
应用免疫组化SP法观察细胞粘附分子CD15和HLA-DR抗原在7例正常肝组织、13例肝硬变（5例伴轻-中度不典型增生）和49例肝细胞癌组织中的表达。结果显示：正常肝组织和肝硬变组织中均无CD15表达，仅肝癌组织中出现CD15的阳性表达，阳性率为30．6％（15／49）；HLA-DR抗原除在正常肝组织、肝硬变伴轻、中度不典型增生病灶和肝癌组织中的肝窦内皮细胞和枯否氏细胞有阳性表达外，22例肝癌细胞中还见阳性染色，阳性率为449％。CD15和HLA-DR的表达与肝癌组织分化程度及是否伴有肝硬化无明显关系（P＞0．05），而与转移有关（P＜0．01）。结果说明肝组织中CD15和HLA-DR的表达变化对肝脏良、恶性病变判断及肝癌患者预后的评估有一定参考意义。
Immunohistochemical SP method was used to observe CD15 and HLA-DR antigens in 7 cases of normal liver tissue, 13 cases of cirrhosis (5 cases with mild-moderate dysplasia) and 49 cases of hepatocellular carcinoma. expression. The results showed that there was no expression of CD15 in normal liver tissue and cirrhosis. Only the positive expression of CD15 was found in liver cancer tissues. The positive rate was 30.6% (15/49); HLA-DR antigen was divided into normal liver tissue, Liver cirrhosis with mild, moderate atypical hyperplasia lesions and liver sinusoidal endothelial cells and Kupffer cells positive expression, 22 cases of liver cancer cells also saw positive staining, the positive rate was 449%. The expression of CD15 and HLA-DR was not significantly related to the degree of differentiation of hepatocellular carcinoma and whether it was associated with liver cirrhosis (P>0.05), but was related to metastasis (P<0.01). The results suggest that the expression changes of CD15 and HLA-DR in liver tissue have certain reference significance for the judgment of benign and malignant liver lesions and the prognosis of liver cancer patients.