应用放射配基结合法测定了人参皂甙Rb_1和Rg_1对α_1,α_2,β肾上腺素能受体、M胆碱能受体、5-羟色胺、多巴胺及GABA等七种受体的作用。结果均不能证明它们对这七种受体有亲和力。但给动物ip药物连续5天,Rb_1和Rg_1均能使中枢M胆碱受体密度显著增高。Rb_1及Rg_1还能显著增加脑内蛋白质的含量。上述实验结果对解释人参的中枢作用提供了重要证据。 The effects of ginsenoside Rb_1 and Rg_1 on seven receptors α_1, α_2, β adrenergic receptor, M cholinergic receptor, 5-hydroxytryptamine, dopamine and GABA were determined by radioligand binding assay. The results can not prove that they have affinity for these seven receptors. But for the animals ip drugs for 5 consecutive days, Rb_1 and Rg_1 can make central M choline receptor density increased significantly. Rb_1 and Rg_1 also significantly increased brain protein content. The above experimental results provide important evidence for explaining the central role of ginseng.