干扰素(IF)抗肿瘤作用研究近年来有较大进展,期望IF能成为有效的生物性抗肿瘤制剂。IF有一定种族特异性,用于人肿瘤研究和治疗的多是人细胞产生的干扰素。 一、抗肿瘤相关病毒作用 乙型肝炎病毒可能与人原发性肝细胞癌相关。IF每次注射后,肝炎患者血清中的病毒标志物都出现剂量相关的下降,特别是DNA聚合酶。长期使用IF则降低作用时间长,停药后能维持数月,肝功能明显改善。研究证实Dane颗粒对IF敏感。IF能减少新生儿巨细胞病毒(CMV)感染时尿中病毒排 The research on the anti-tumor effect of interferon (IF) has made great progress in recent years, and it is expected that IF can become an effective biological anti-tumor agent. IF has a certain ethnic specificity, and most of the studies and treatments for human cancers are interferons produced by human cells. First, the role of anti-tumor virus Hepatitis B virus may be related to human primary hepatocellular carcinoma. After each injection of IF, there was a dose-related decrease in viral markers in the serum of hepatitis patients, particularly DNA polymerase. The long-term use of IF reduces the duration of the action, and can last for several months after discontinuation of the drug. Liver function is significantly improved. Studies confirm that Dane particles are sensitive to IF. IF reduces neonatal cytomegalovirus (CMV) infection in urine during viral row