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目的分析胰岛素强化治疗对2型糖尿病患者炎症因子的影响。方法抽选本院收治的86例2型糖尿病患者,分别采用持续胰岛素皮下输注(CSII)和多次皮下胰岛素注射(MSII)强化方法进行治疗,比较两组治疗前后的糖化血红蛋白(HbA1c)、炎症因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的变化。结果两组患者治疗前,血糖无明显变化,治疗后两组血糖比较,P<0.05,差异有统计学意义,治疗后两组患者血清的CRP、TNF-α水平明显下降,但两组比较,P>0.05,差异无统计学意义。结论采用CSII和MSII两种方法均能有效控制2型糖尿病患者的血糖水平,同时可有效减少血清C反应蛋白水平,其中CSII方法控制血糖水平更为显著。
Objective To analyze the effect of intensive insulin therapy on inflammatory cytokines in type 2 diabetic patients. Methods Totally 86 patients with type 2 diabetes mellitus were enrolled and treated with continuous subcutaneous insulin infusion (CSII) and multiple subcutaneous insulin injections (MSII). The levels of HbA1c, Changes of inflammatory factor C-reactive protein (CRP), tumor necrosis factor-α (TNF-α). Results Before treatment, there was no significant difference in blood glucose between the two groups. After treatment, the blood glucose of the two groups was significantly lower than that before treatment (P <0.05), and the difference was statistically significant. After treatment, serum CRP and TNF-α levels decreased significantly in both groups, P> 0.05, the difference was not statistically significant. Conclusion Both CSII and MSII can effectively control blood glucose levels in patients with type 2 diabetes mellitus, and can effectively reduce serum C-reactive protein levels, of which the CSII method controls blood glucose levels more significantly.