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化疗药物联合治疗能提高单一药物的治疗效果,是目前临床肿瘤治疗的主要模式,但由于化疗药物特异性差、不良反应较大,限制了其临床应用。纳米给药系统共递送化疗药物能够大大提高治疗效果并有效减轻不良反应,具有广阔的前景,但在设计、制备以及控制同步释放等问题上仍面临着诸多挑战。本文综述了近年来纳米载体共递送化疗药物用于肿瘤联合治疗的研究进展,并对纳米给药系统共递送化疗药物的性能要求进行探讨。
Combination therapy of chemotherapy drugs can improve the therapeutic effect of single drug, which is the main mode of clinical oncology treatment at present. However, due to the poor specificity of chemotherapy drugs and large adverse reactions, its clinical application is limited. The co-delivery of chemotherapeutic drugs by nano-drug delivery system can greatly improve the therapeutic effect and reduce adverse reactions. It has broad prospects but still faces many challenges in the design, preparation and control of simultaneous release. This review summarizes the recent advances in the co-delivery of chemotherapeutics with nanocarriers for the combination therapy of tumors, and discusses the performance requirements for co-delivery of chemotherapeutic drugs in nanodialysis delivery systems.