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目的研究肺结核以及肺癌所致的胸水中趋化因子(调节活化正常T细胞表达)和分泌因子(RANTES)的表达水平及临床意义。方法用酶联免疫吸附法(ELISA)测定22例肺结核,15例肺癌患者以及正常对照20例血清和/或胸水中RANTES的水平。结果肺癌患者血清及胸水中RANTES水平升高较肺结核患者升高明显。结论趋化因子在结核和肿瘤中发挥不同的T细胞免疫应答,为以后的应用奠定实验基础。
Objective To study the expression of chemokines (regulate the expression of activated normal T cells) and secretion factor (RANTES) in pleural effusion caused by pulmonary tuberculosis and lung cancer and its clinical significance. Methods The levels of RANTES in serum and / or pleural effusion of 22 patients with pulmonary tuberculosis, 15 patients with lung cancer and 20 normal controls were determined by enzyme-linked immunosorbent assay (ELISA). Results The serum RANTES levels in patients with lung cancer and pleural effusion were significantly higher than those in patients with pulmonary tuberculosis. Conclusions Chemokines exert different T cell immune responses in tuberculosis and tumors, laying an experimental foundation for future application.