【摘 要】
：
目的 探讨血清高尔基体蛋白73(GP73)在原发性肝癌(primary hepatic carcinoma,PHC)患者血清中的表达及其临床意义.方法 采用酶联免疫吸附试验(ELISA)检测我院收治的47例PHC(
【机 构】
：
武警河北总队医院传染科,武警医学院附属医院肿瘤外科
论文部分内容阅读
目的 探讨血清高尔基体蛋白73(GP73)在原发性肝癌(primary hepatic carcinoma,PHC)患者血清中的表达及其临床意义.方法 采用酶联免疫吸附试验(ELISA)检测我院收治的47例PHC(肝癌组)及40例肝硬化(肝硬化组)血清中GP73,同时用电化学发光法检测血清甲胎蛋白(AFP),并将检测结果进行对比.结果 GP73和AFP测定值肝癌组分别为(220.44±89.71) μg/L、(404.06±135.43) μg/L,肝硬化组分别为(112.67 +34.89) μg/L、(71.17±16.24) μg/L,组间比较差异均有统计学意义(t=93.485,t=250.924；P均＜0.001).GP73和AFP阳性率肝癌组分别为85.11％ (40/47)、61.70％(29/47),肝硬化组分别为15.00％ (6/40)、22.50％(9/40),组间比较差异均有统计学意义(X2=70.654,X2=31.284;P均＜0.001).肝癌组GP73异常与合并肝硬化或淋巴结转移有关(t=2.061,=2.133；P均＜0.05),与肿瘤大小及临床分期无关(t=0.560,t=0.573;P均＞0.05).结论 肝癌患者血清高表达GP73,可能与肝癌的发生、发展有关,检测GP73有助于PHC早期诊断.
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