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大鼠中脑上端切断模型３０只，随机等分为Ａ、Ｂ、Ｃ３组，经尾静脉分别注入蝎毒素Ⅳ（ＳＶＣ－Ⅳ）１３０μｇ／ｋｇ，吗啡６００μｇ／ｋｇ及生理盐水，以大鼠缩腿潜伏期和屈肌反射为测痛指标，观察ＳＶＣ－Ⅳ尾静脉注入后的镇痛作用并与吗啡的作用进行比较。结果：Ａ组ＳＶＣ－Ⅳ注入后３０ｍｉｎ之内缩腿潜伏期明显延长，２０ｍｉｎ左右延长最明显，屈肌反射Ａ波波幅于１０～４０ｍｉｎ内明显受到压抑，２０ｍｉｎ左右最大Ａ波抑制率为（９６．１±８．９）％；Ｂ组吗啡注入后Ａ波波幅的压抑限于１０～４０ｍｉｎ，３０ｍｉｎＡ波最大抑制率为（８７．４±８．２）％；Ｃ组屈肌反射无明显变化。结果提示：ＳＶＣ－Ⅳ静脉给药具有镇痛作用，其镇痛作用强于吗啡。
Thirty rats were randomly divided into 3 groups: A, B and C3 groups. Rats were injected with 130 μg / kg SVC-Ⅳ, 600 μg / kg morphine and saline, The latency of leg and flexor reflex were the indexes of analgesia. The analgesic effect after SVC-IV tail vein injection was observed and compared with that of morphine. Results: Within 30 minutes after injection of SVC-Ⅳ, the latent period of leg contraction was significantly prolonged in group A, and the most obvious prolongation was observed in 20 minutes. The amplitude of A wave in flexor reflex was obviously suppressed in 10-40 minutes, and the maximum A wave inhibition rate was 20 minutes in 96 hours. 1 ± 8.9%). The inhibition of A wave amplitude in group B after morphine injection was limited to 10-40 minutes, and the maximum inhibition rate was (87.4 ± 8.2)% at 30 minutes. There was no significant change in group C. The results suggest that intravenous administration of SVC-IV has analgesic effect and its analgesic effect is stronger than that of morphine.