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实验用０．２％和０．０５％多虑平贴膏溶液抗２，４一二硝基氯苯所致小鼠皮肤过敏反应。降低小鼠耳肿胀重量分别为１１．４±１．３和１１．６±１１．２ｍｇ，生理盐水（ＮＳ）为１５．９±２．２ｍｇ（Ｐ＜０．０１）；抗组胺所致大鼠皮肤血管扩张面积分别为０．０４±０．０６和０．４０±０．５４ｃｍ￣２，ＮＳ为１．４２±０．７１ｃｍ￣２（Ｐ＜０．０１）；提高组胺对豚鼠的致痒阈分别为６３５．５±９９和１５８±４３ｍｇ，ＮＳ为３０±２９．４μｇ（Ｐ＜０．０１）；抗炎性刺激所致毛细血管通透性吸光度分别为０．１７±０．０５和０．２０±０．１３，ＮＳ为０．３９±０．０６（Ｐ＜０．０１）。结果表明多虑平贴膏有很强的抗过敏作用，是一种新型抗过敏制剂。
Experiment with 0.2% and 0.05% doxepin cream solution anti-2,4-dinitrochlorobenzene-induced skin allergic reaction in mice. Reduced mice ear edema weight were 11.4 ± 1.3 and 11.6 ± 11.2mg, NS (15.9 ± 2.2mg (P <0.01); antihistamine Rat skin vasodilatation area was 0.04 ± 0.06 and 0.40 ± 0.54cm ~ 2, NS was 1.42 ± 0.71cm ~ 2 (P <0.01); improve histamine on guinea pigs Of itching threshold were 635.5 ± 99 and 158 ± 43mg respectively, and NS was 30 ± 29.4μg (P <0.01). The absorbance of capillary permeability induced by anti-inflammatory stimulus was 0.17 ± 0 .05 and 0.20 ± 0.13, NS was 0.39 ± 0.06 (P <0.01). The results show that Doudin paste has a strong anti-allergic effect, is a new type of anti-allergic agents.