亮石松碱(Selagine)是一种植物碱,其结构式如左所示。 亮石松碱用于处理青光眼,能使瞳孔缩小,降低眼内压。最近浙江省人民卫生实验院药物研究所发现它有很强的加强肌肉收缩作用。本文研制了氚标记亮石松碱,这对研究亮石松碱在动物体内的吸收、分布、排泄等代谢规律有重要的意义。 Selagine is a plant alkaloid with the structural formula shown on the left. Lysine is used to treat glaucoma, can make the pupil shrink, reduce intraocular pressure. Recently, Zhejiang Provincial Institute of People’s Health Drug Discovery Institute found it has a strong strengthening of muscle contraction. In this paper, tritiated lanthanide was developed, which is of great significance for the study of the absorption, distribution and excretion of linalpine in animals.