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目的研究子宫颈癌中C-erbB-2基因的表达,探讨C-erbB-2在宫颈癌发生发展中的作用,及作为一种肿瘤标记物用于临床筛查判断和判断预后的临床意义。方法应用免疫组织化学的方法检测C-erbB-2基因在宫颈癌32例,慢性宫颈炎20例(对照组)的表达。用卡方检验(Chi-Square Test)检测C-erbB-2在实验组和对照组中的表达是否有差异。结果C-erbB-2在慢性宫颈炎、宫颈癌组织中的阳性表达率分别为68.75%、30%,两者间具有统计学意义(P<0.05),C-erbB-2的表达与宫颈癌的临床分期呈正相关(P0.01)。结论C-erbB-2作为影响细胞凋亡因子,在宫颈癌的发生、发展过程中起一定作用。
Objective To study the expression of C-erbB-2 gene in cervical cancer and to explore the role of C-erbB-2 in the development of cervical cancer and its clinical significance as a tumor marker for clinical screening and prognosis. Methods Immunohistochemistry was used to detect the expression of C-erbB-2 gene in 32 cases of cervical cancer and 20 cases of chronic cervicitis (control group). Chi-Square Test was used to detect the difference of C-erbB-2 expression between the experimental group and the control group. Results The positive rates of C-erbB-2 in chronic cervicitis and cervical cancer were 68.75% and 30%, respectively (P <0.05). The positive rates of C-erbB-2 and cervical cancer The clinical stage was positively correlated (P <0.01). Conclusions C-erbB-2 plays an important role in the development and progression of cervical cancer as an apoptosis-inducing factor.