应用单克隆抗体（ ＭｃＡｂ）间接免疫荧光法检测２８ 例幼年类风湿性关节炎患儿血清Ｔ 细胞免疫功能及其亚群分布以及Ｂ细胞、ＮＫ 细胞活性；应用单向免疫琼脂扩散法测定其免疫球蛋白及补体Ｃ３ 水平。结果：患儿组ＣＤ４ 较对照组明显升高、ＣＤ８ 明显降低，ＣＤ４／ＣＤ８ 比值明显升高；Ｂ 细胞活性增强；ＮＫ 细胞活性明显增强（ Ｐ均＜ ０－０１） ；患儿组ＩｇＧ、ＩｇＭ 及补体Ｃ３较对照组明显升高（Ｐ均＜ ０－０１） 。提示幼年型类风湿性关节炎患儿病变活动期存在明显细胞和体液免疫功能同时紊乱。 Serum T cell immune function, subgroup distribution and B cell and NK cell activity in 28 juvenile rheumatoid arthritis children were detected by indirect immunofluorescence with monoclonal antibody (McAb). Immunity was measured by one-way immunogold agar diffusion Globulin and complement C3 levels. Results: Compared with the control group, CD4 was significantly increased, CD8 was significantly decreased, CD4 / CD8 ratio was significantly increased, B cell activity was enhanced, and NK cell activity was significantly increased (all P <0-01) And complement C3 were significantly higher than the control group (all P <0-01). Tip juvenile rheumatoid arthritis in children with significant active disease cells and humoral immune function at the same time disorder.