论文部分内容阅读
目的 : 在山区血吸虫病流行区观察口服蒿甲醚 ( Art)对控制血吸虫病的作用。方法 :选择云南省永胜县阳河的 8个自然村为试区。该试区钉螺感染率为 0 .38% ,感染螺平均密度为 0 .0 0 86只 / 0 .11m2 ,居民感染率为 18.2 %。将 8个自然村随机配对分为 Art组和对照组 ,并以试区内3- 60岁经常接触疫水的居民为观察对象 ,经粪检血吸虫卵阳性者口服 1次吡喹酮 50 mg/ kg治疗 ,血吸虫卵阴性者服 4 0 mg/ kg。观察对象于 5月下旬接触疫水半个月后 ,按双盲法服首剂 Art 6mg/ kg,对照组服安慰剂 ,以后每半个月服 1次 ,共 10次。末次服药后 1个月作粪检。结果 :Art组789人的粪检阳性率为 2 .9% ,对照组 717人的为 12 .1% ,两者的差异显著。对照组尚有 1例急性血吸虫病发生。结论 :在山区较重的血吸虫病流行区 ,于整个传播季节口服 Art,可明显降低居民重复感染血吸虫 ,有效地控制血吸虫病。
OBJECTIVE: To observe the effect of artemether on the control of schistosomiasis in the endemic area of schistosomiasis in mountainous areas. Methods: Eight natural villages in Yanghe, Yongsheng County, Yunnan Province were selected as the pilot area. The infection rate of snails in this test area was 0.38%, and the mean density of infected snails was 0.086 / 0.1 1m2 with a resident infection rate of 18.2%. Eight natural villages were randomly assigned to Art group and control group. The residents who were exposed to the polluted water frequently aged 3-60 years in the test area were enrolled in this study. Praziquantel 50 mg / kg Treatment, Schistosoma japonicum egg negative service 40 mg / kg. Subjects in contact with the epidemic in late May half a month later, the first dose of double-blind treatment Art 6mg / kg, the control group taking placebo, once every two weeks for a total of 10 times. 1 month after the last dose for fecal examination. Results: In the Art group, the positive rate of feces of 789 people was 2. 9% and that of the control group was 12.1%. There was significant difference between the two. One case of acute schistosomiasis occurred in the control group. Conclusion: In the endemic area of severe schistosomiasis in mountainous area, oral administration of Art for the entire spreading season can significantly reduce the residents’ repeated infection of schistosomiasis and effectively control schistosomiasis.