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胃癌的发病率占全部恶性肿瘤的首位。为了进一步探讨中医方药对胃癌疗效的机理,我们将人体胃腺癌细胞株SGC-7901移植于裸鼠皮下及腹腔内,经过半年的实验观察以及病理切片、染色体、组化染色及透射电镜超微结构检查均证实,在裸鼠体内生长的肿瘤细胞仍保持了人癌细胞的结构。这一模型的建立,对在活体上筛选有效抗癌药物具有一定的实用价值。
The incidence of gastric cancer accounts for the top of all malignant tumors. In order to further explore the mechanism of traditional Chinese medicine prescriptions for gastric cancer, we transplanted human gastric adenocarcinoma cell line SGC-7901 into subcutaneous and intraperitoneal nude mice. After six months of experimental observation and pathological sections, chromosomes, histochemical staining and transmission electron microscopy ultrastructure Examinations have confirmed that tumor cells growing in nude mice still maintain the structure of human cancer cells. The establishment of this model has practical value for screening effective anti-cancer drugs on the living body.