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[目的]探讨D2-40在恶性胸膜间皮瘤诊断中的潜在价值。[方法]对余姚市人民医院及复旦大学附属中山医院病理科自1999～2009年诊断的31例恶性胸膜间皮瘤和30例肺腺癌进行回顾性分析并进行免疫组化检测,观察D2-40、Calretinin、CEA、TTF-1在恶性间皮瘤和肺腺癌中的表达。[结果]D2-40、Calretinin在恶性胸膜间皮瘤中的灵敏度分别为80.6%、83.9%,特异性分别为93.3%、86.7%,两者联合诊断的灵敏度93.5%,其中上皮型间皮瘤为100.0%。CEA、TTF-1在肺腺癌中的灵敏度分别为90.0%、83.3%,特异性分别为87.1%和100.0%。[结论]D2-40联合Calretinin可以提高恶性胸膜间皮瘤鉴别诊断的准确率。D2-40、Calretinin、CEA、TTF-1联合检测是鉴别恶性胸膜间皮瘤和肺腺癌的一组有价值的抗体。
[Objective] To investigate the potential value of D2-40 in the diagnosis of malignant pleural mesothelioma. [Methods] 31 cases of malignant pleural mesothelioma and 30 cases of lung adenocarcinoma diagnosed in Yuyao People’s Hospital and Zhongshan Hospital Affiliated to Fudan University from 1999 to 2009 were retrospectively analyzed and immunohistochemically examined. The results of D2- 40, Calretinin, CEA, TTF-1 in malignant mesothelioma and lung adenocarcinoma. [Results] The sensitivity of D2-40 and Calretinin in malignant pleural mesothelioma was 80.6% and 83.9%, respectively, the specificity was 93.3% and 86.7%, respectively. The sensitivity of combined diagnosis of them was 93.5% Is 100.0%. The sensitivity of CEA and TTF-1 in lung adenocarcinoma were 90.0% and 83.3% respectively, and the specificity was 87.1% and 100.0% respectively. [Conclusion] The combination of D2-40 and Calretinin can improve the accuracy of differential diagnosis of malignant pleural mesothelioma. D2-40, Calretinin, CEA, TTF-1 combined detection is a group of valuable antibodies to differentiate malignant pleural mesothelioma and lung adenocarcinoma.