A practical procedure for palladium catalyzed Suzuki cross-coupling reaction of arylboronic acids with aryl hal-ides, including aryl chlorides in molten tetra-n-butylammonium bromide (TBAB) was developed. The reaction exhibits high efficiency and functional group tolerance. The recovery of the catalyst and molten n-Bu4NBr was also investigated. A practical procedure for palladium catalyzed Suzuki cross-coupling reaction of arylboronic acids with aryl hal-ides, including aryl chlorides in molten tetra-n-butylammonium bromide (TBAB) was developed. The reaction exhibits high efficiency and functional group tolerance. The recovery of the catalyst and molten n-Bu4NBr was also investigated.