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药物性吸收不良是一种较常见的医源性疾患,其发生机理为:①药物导致小肠粘膜形态学损害;②干扰小肠粘膜和细胞内酶的活力;③沉淀微胶粒物质,如胆盐和脂肪酸;④改变另一种药物或食物内铁的物理、化学性质。易导致吸收不良的药物有以下几种: 一、新霉素该药可损害小肠粘膜,导致绒毛缩短,固有膜淋巴细胞和巨噬细胞浸润;并能沉淀微胶粒中的脂肪酸和胆盐;可逆性抑制小肠粘膜刷状缘双糖酶的活力。
Drug-induced malabsorption is a more common iatrogenic disease, its mechanism is as follows: ① drugs cause small intestinal mucosal morphological damage; ② interfere with intestinal mucosa and intracellular enzyme activity; ③ precipitation of micellar substances, such as bile salts And fatty acids; ④ change the physical or chemical properties of iron in another drug or food. Easily lead to malabsorption of drugs are the following: First, neomycin The drug can damage the small intestine mucosa, resulting in villi shortened, inherent membranous lymphocytes and macrophages infiltration; and can precipitate the micelles of fatty acids and bile salts; Reversible inhibition of intestinal mucosal brush border disaccharidase activity.