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AIM: To study the effect of S-21007, a 5-HT_3partial agonist in different animal models of anxiety inmice. METHODS: S-21007 effects were evaluatedin the behavior tests after intraperitioneal and oral acutetreatment or in the light/dark test after both acute andchronic treatments. RESULTS: S-21007 presentedanxiolytic-like properties after acute administration inthe light/dark box test, the mirrored chamber test, andthe elevated plus-maze at be doses 10 ng·kg~(-1)-100μg·kg~(-1), 1-100 μg·kg~(-1) and 10-100 μg·kg~(-1),respectively. In the light/dark box test, S-21007 wasactive orally after acute treatment at 100 ng·kg~(-1)-10mg·kg~(-1) and after chronic treatment (14 d) at 1-10μg·kg~(-1). S-21007 was devoid of sedative or stimula-
AIM: To study the effect of S-21007, a 5-HT_3partial agonist in different animal models of anxiety in mice. METHODS: S-21007 effects were evaluated in the behavior tests after intraperitioneal and oral acute treatment or in the light / dark test after both acute and chronic treatments. RESULTS: S-21007 presentedanxiolytic-like properties after acute administration of inthe light / dark box test, the mirrored chamber test, and the elevated plus-maze at be doses 10 ng · kg -1 -100 μg · kg -1 -1), 1-100 μg · kg -1 and 10-100 μg · kg -1, respectively. In the light / dark box test, S-21007 was active orally after acute treatment at 100 ng · (-1) -10 mg · kg -1 and after chronic treatment (14 d) at 1-10 μg · kg -1 S-21007 was devoid of sedative or stimula-