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目的:分析2012~2013年我院新生儿败血症病原菌及其耐药情况,为临床合理用药提供依据。方法:采用回顾性对比分析,以2012~2013年我院收治的68例患儿为研究对象,观察病原菌及耐药性情况变迁趋势。结果:2012年最主要病原菌为金黄色葡萄球菌;2013年则为凝固酶阴性葡萄球菌(CNS)。两年内CNS和金黄色葡萄球菌为最主要病原菌,分别占33.8%和22.1%。CNS对氨曲南、氨苄西林、头孢哌酮、美洛培南耐药性均有上升;金黄色葡萄球菌对青霉素、头孢曲松耐药性均有上升。两年内CNS对头孢曲松、环丙沙星、亚胺培南、头孢噻肟等耐药率较低,金黄色葡萄球菌对亚胺培南、头孢噻肟、哌拉西林耐药率较低;大肠埃希菌对亚胺培南、环丙沙星、哌拉西林敏感性良好。结论:CNS为我院新生儿败血症主要病原菌,其对氨曲南、氨苄西林、美洛培南、庆大霉素等抗菌药耐药性水平较高,万古霉素可作为首选治疗药物。
Objective: To analyze the pathogenic bacteria and drug resistance of neonatal sepsis in our hospital from 2012 to 2013, and to provide basis for clinical rational drug use. Methods: A retrospective comparative analysis was carried out in 68 infants admitted to our hospital from 2012 to 2013. The changes of pathogens and drug resistance were observed. Results: The most important pathogen in 2012 was Staphylococcus aureus; in 2013 it was coagulase-negative staphylococcus (CNS). In two years, CNS and Staphylococcus aureus were the most important pathogens, accounting for 33.8% and 22.1% respectively. CNS resistance to aztreonam, ampicillin, cefoperazone, meropenem increased; Staphylococcus aureus penicillin, ceftriaxone resistance increased. The drug resistance rates of CNS to ceftriaxone, ciprofloxacin, imipenem and cefotaxime were low in two years. The rates of resistance of S. aureus to imipenem, cefotaxime and piperacillin were low Escherichia coli was sensitive to imipenem, ciprofloxacin and piperacillin. CONCLUSIONS: CNS is the main pathogen of neonatal sepsis in our hospital. Its drug resistance to aztreonam, ampicillin, meropenem and gentamicin is high. Vancomycin is the first choice of treatment.