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目的 :探讨在直线扫描方式时 ,高强度聚焦超声 (HIFU)损伤不同深度的正常羊肝组织的治疗剂量 ,即产生单位体积凝固性坏死所需要的超声输出能量。方法 :应用频率 1.0 MHz,焦域平均声强为 5 5 0 0 W/ cm2 ,对 15头南疆黄羊距皮肤 30 mm、 4 0 mm、 5 0 mm的肝组织内行 HIFU损伤 ,损伤范围 30 mm× 10 mm× 10 mm,扫描线间距和面间距均为 5 mm。术后 3～ 7天内处死动物 ,测量凝固性坏死体积 ,观察治疗剂量与治疗深度的关系。结果 :距皮30 mm深度肝脏 HIFU治疗剂量为 (16 .6± 2 .72 ) J/ mm3,4 0 mm为 (2 8.3± 6 .37) J/ mm3,5 0 mm为 (44 .7± 3.71)J/ mm3。结论 :HIFU致肝组织的凝固性坏死有明显的量效关系 ,其值随辐照深度的增加而增加
Objective : To investigate the therapeutic dose of normal goat liver tissue at different depths after high-intensity focused ultrasound (HIFU) in the linear scan mode, which is the ultrasonic output energy needed to produce coagulative necrosis per unit volume. METHODS: The frequency of application was 1.0 MHz, and the mean focal intensity of the focal region was 550 W/cm2. HIFU lesions were observed in 15 livers of 30 mm, 40 mm, and 50 mm from the skin of southern goats in Southern Xinjiang. The lesion range was 30. Mm × 10 mm × 10 mm, scanning line spacing and surface spacing are 5 mm. Animals were sacrificed within 3 to 7 days after surgery. The volume of coagulative necrosis was measured and the relationship between the therapeutic dose and the depth of treatment was observed. RESULTS: The HIFU treatment dose was (16 .6± 2.72) J/mm3 for 30 mm depth from the skin, (2 8.3±6.37) J/mm3 for 40 mm, and (44.7±5.0 mm for 50 mm). 3.71)J/mm3. Conclusion: The coagulation necrosis of hepatic tissue induced by HIFU has a significant dose-effect relationship, and its value increases with the increase of irradiation depth.