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本研究验证强心咪啶(MD)对豚鼠离体心房的作用,并与异丙肾上腺素(ISO)作了比较。在以恒定电刺激驱动的左心房上观察药物的正性肌力作用;在自发跳动的右心房上观测药物的正性频率作用。结果表明:(1)MD类似ISO具有较强的正性肌力作用,在蓄积给药条件下呈现较好的量-效关系;(2)MD也有一定的正性频率作用,但比ISO弱得多;(3)在单次给药条件下,MD正性肌力作用的发展比较缓慢,但能比较持久地不断增强,而ISO的作用发展比较急骤;(4)心得安能显著地对抗ISO的正性肌力和正性频率作用,但几乎不影响MD的这两种作用。提示MD非β_1受体兴奋药。以上研究结果与国外报道近似。
This study validates the effect of cardiac troponin (MD) on guinea pig isolated atria and compares it with isoproterenol (ISO). The positive inotropic effect of the drug was observed on the left atrium driven by constant electrical stimulation; the positive frequency of the drug was observed on the spontaneous beating right atrium. The results showed that: (1) MD had a similar positive inotropic effect on ISO and had a good dose-effect relationship under the conditions of cumulative administration; (2) MD also had some positive frequency effects but was weaker than ISO (3) In a single administration, MD positive inotropic effect developed more slowly, but lasting more continuously, while the role of ISO was more rapid development; (4) propranolol can significantly counteract The positive inotropic and positive frequency effects of ISO, but with little effect on both MD roles. Tip MD non-beta 1 receptor agonist. The above findings are similar to those reported abroad.