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目的:观察中西医结合治疗原发性肾病综合征的临床疗效。方法将117例原发性肾病综合征患者随机分为治疗组和对照组,治疗组59例,对照组57例,对照组采用单纯西药治疗,治疗组采用中西医结合治疗。观察两组总体疗效及两组患者治疗前后尿蛋白和血浆白蛋白的变化,并观察两组的毒副反应。结果:治疗组总有效率91.5%,对照组总有效率79.3%,差异有显著性(χ2=3.90,P<0.05);治疗组治疗后血浆白蛋白明显升高,尿蛋白明显减少,与治疗组治疗后比较差异有显著性(P<0.05);同时,治疗组和对照组副作用发生率分别是37.2%和87.9%,差异有非常显著性(χ2=28.9,P<0.005)。结论:中西医结合治疗原发性肾病综合征能增加机体对激素的敏感性,从而提高疗效,并减少激素毒副作用,确保激素的安全撤减,降低复发率,优于单纯西医治疗。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of primary nephrotic syndrome. Methods A total of 117 patients with primary nephrotic syndrome were randomly divided into treatment group and control group. The treatment group was 59 cases and the control group 57 cases. The control group was treated with western medicine alone. The treatment group was treated with integrated traditional Chinese and western medicine. The overall curative effect and the changes of urinary protein and plasma albumin before and after treatment in both groups were observed, and the toxic and side effects of the two groups were observed. Results: The total effective rate was 91.5% in the treatment group and 79.3% in the control group, with significant difference (χ2 = 3.90, P <0.05). After treatment, the serum albumin was significantly increased and the urine protein was significantly decreased The difference between the two groups was significant (P <0.05). At the same time, the incidence of side effects in the treatment group and the control group were 37.2% and 87.9%, respectively. The difference was significant (χ2 = 28.9, P <0.005). Conclusion: The combination of traditional Chinese and Western medicine treatment of primary nephrotic syndrome can increase the sensitivity of the body to the hormone, thereby enhancing the efficacy and reduce the side effects of hormones to ensure the safe withdrawal of hormones and reduce the recurrence rate, superior to Western medicine alone.