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目的:长期腹膜透析病人经透析液和尿液丢失的微量元素量,是临床营养支持的重要依据,但相关研究甚少,对此进行探索。方法:对收集到透析液和尿液的50例患者进行调查,用电感耦合等离子体质谱仪(ICP-MS)测定透析液与尿液中微量元素的浓度,计算并分析患者微量元素的丢失量及影响因素。结果:患者每天经由尿液和透析液总丢失Fe,Zn,Se,Cr,Cu,Mn,Mo,Co元素的量分别为1088.45μg、1156.11μg、15.89μg、33.85μg、390.96μg、66.47μg、191.25μg、0.56μg,通过多元线性回归分析发现这些元素丢失水平分别受到不同因素影响。结论:相较于尿液,透析液是CAPD患者丢失矿物质的主要途径,在临床营养支持中应根据不同监测指标预判断元素的丢失水平,防止营养缺乏的发生。
Objective: Long-term peritoneal dialysis patients dialysis fluid and urine loss of trace elements, is an important basis for clinical nutritional support, but little research, to explore this. Methods: Fifty patients with dialysate and urine collected were investigated. The concentrations of trace elements in dialysate and urine were determined by inductively coupled plasma mass spectrometry (ICP-MS), and the loss of trace elements was calculated and analyzed Volume and influencing factors. Results: The total amount of Fe, Zn, Se, Cr, Cu, Mn, Mo and Co elements lost to urine and dialysis fluid per day were 1088.45μg, 1156.11μg, 15.89μg, 33.85μg, 390.96μg and 66.47μg, 191.25μg, 0.56μg, respectively, by multiple linear regression analysis found that the loss of these elements were affected by different factors. Conclusion: Compared with urine, dialysate is the main way to lose minerals in patients with CAPD. In the clinical nutrition support, the loss of elements should be pre-judged according to different monitoring indicators to prevent the occurrence of nutritional deficiencies.