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本实验以二甲肼[1,2-Dimethylhydrazine,DMH]为致癌剂诱发大鼠大肠癌。电镜观察24只大鼠在DMH作用下,不同时相点,大肠粘膜显示不同程度的病变。实验10～15周主要表现为粘膜不典型增生,超微结构改变主要显示细胞膜不规则或皱褶,核增大、微绒毛不规则。第16～32周以后肿瘤形成,胞核显著增大,异染色质增多,胞质内分泌颗粒减少,游离核蛋白体增多、细胞膜表面微绒毛不规则,细胞膜之间的桥粒减少,此种改变为大肠癌的超微结构特征。
In this experiment, 1,2-Dimethylhydrazine (DMH) was used as a carcinogen to induce colorectal cancer in rats. Electron microscopy observation of 24 rats under the action of DMH, different time points, the colorectal mucosa showed varying degrees of lesions. The main manifestations of the 10-15 weeks of the experiment were dysplasia of the mucous membranes. The ultrastructural changes mainly showed irregular cell membranes or folds, and the nuclear enlargement and microvilli were irregular. After the 16th to the 32nd week, the tumor formed, the nuclei increased significantly, the heterochromatin increased, the cytoplasmic endocrine granules decreased, the free ribosome increased, the microvilli on the cell membrane surface was irregular, and the desmosomes between cell membranes decreased. For the ultrastructure characteristics of colorectal cancer.