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1.前言抗菌素的研究从开始到现在已有40年了,新物质的探索及发现是很多的,已经整理成一个庞大的知识体系。特别是由于抗菌素的化学及生物化学的进展,阐明了它的作用机制,结构和活性之间的关系已较明确地从分子水平来讨论。因此,近几年来关于抗菌素改造的研究,相当活跃地开展起来。抗菌素的改造是为了寻找更好的比原物质活性强、抗菌谱广、比较稳定、毒性小,吸收及排泄好的物质。特别是近几年来对于正在增加的耐药菌有效的化合物得到重视,
1. Introduction Antimicrobial research has been 40 years since its inception. Discovery and discovery of new substances are numerous and have been organized into a vast body of knowledge. In particular, due to advances in the chemical and biochemicals of antibiotics, elucidation of its mechanism of action, the relationship between structure and activity has been more explicitly discussed at the molecular level. Therefore, the research on the modification of antibiotics in recent years has started quite actively. The transformation of antibiotics is to find better than the original material activity, broad antibacterial spectrum, more stable, less toxic, good absorption and excretion of substances. In particular, compounds that are effective against the increasing number of resistant bacteria have been given priority in recent years,