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目的:探讨多囊卵巢综合征(PCOS)不孕症患者采用达英-35预处理前后泌乳素的变化及其对促排卵及妊娠结局的影响。方法:选择PCOS不孕患者112例,应用达英-35进行助孕前预处理3个周期,分析预处理前后血清泌乳素的变化。将预处理后PCOS不孕患者据血清PRL水平分为两组:A组(高PRL血症组),B组(未伴有高PRL血症组)。结果:基础血PRL正常的PCOS不孕患者在达英-35预处理3个周期后,32.6%可继发高PRL血症;预处理后血PRL变化值与基础PRL、LH/FSH、T、BMI均无相关关系(P>0.05)。A组与B组比较促排卵过程中尿促性素(HMG)用量显著增加(P<0.05),而排卵率显著降低(P<0.01),妊娠率A组低于B组,但差异无统计学意义。结论:达英-35预处理后可使部分PCOS患者继发高PRL血症,但与其基础生殖内分泌状态及BMI无相关性。预处理后的高PRL血症可影响PCOS患者的促排卵及妊娠结局。
Objective: To investigate the changes of prolactin in patients with polycystic ovary syndrome (PCOS) infertility before and after oral administration of da-Ying35 and its effect on ovulation induction and pregnancy outcome. Methods: One hundred and two patients with PCOS infertility were selected. Three weeks before preconditioning were performed using Dayang-35, the changes of serum prolactin before and after pretreatment were analyzed. Pretreatment PCOS infertility patients according to serum PRL levels were divided into two groups: A group (high PRL hyperlipidemia group), B group (not associated with high PRL hyperlipidemia group). Results: 32.6% of patients with PCOS infertility who had normal PRL in normal PCL group had high PRL after 32 weeks of pretreatment with Ying-35 pretreatment. The changes of PRL, LH / FSH, T, BMI had no correlation (P> 0.05). In group A and group B, the amount of urinary HMG increased significantly (P <0.05) and the rate of ovulation decreased significantly (P <0.01). The pregnancy rate in group A was lower than that in group B, but the difference was not statistically significant Significance of learning. Conclusion: Da-Ying-35 pretreatment can make some patients with PCOS secondary high PRL hyperlipidemia, but with its basic reproductive and endocrine status and no correlation between BMI. Pretreatment of hyperprolactinemia can affect ovulation and pregnancy outcomes in PCOS patients.