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本文报道应用 Univar 显微分光光度计对长期饲以50ppm 含氟水造成慢性氟中毒大鼠的肝、肾组织中的酸性磷酸酶活性进行测量研究,发现氟中毒大鼠肝、肾酸性磷酸酶的活性均较对照组明显降低,同时光镜下出现肝细胞坏死、肾曲管上皮局灶性坏死及基底膜崩解等病理形态变化。
This paper reports the use of Univar Microspectrophotometer to measure the acid phosphatase activity in liver and kidney tissues of rats with chronic fluorosis caused by long-term feeding of 50ppm fluorine-containing water, and found that liver phosphatase in liver and kidney of rats with fluorosis. Compared with the control group, the activity was significantly reduced. At the same time, pathological changes such as hepatocyte necrosis, focal necrosis of the renal canalicular epithelium and disintegration of the basement membrane were observed under light microscope.