目的评价以急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)分值量化的形式对矽肺患者急性加重期的预后判断。方法选择2005年1月至2009年12月矽肺急性加重期合并呼吸衰竭入住本院ICU238例患者的临床资料,对所有病例进行APACHEⅡ评分。结果 APACHEⅡ≤10分组,无死亡病例;11～19分组病死率25.00%;20～29分组病死率68.18%;≥30分组病死率为92.86%。结论 APACHEⅡ评分可以用来预测ICU矽肺患者急性加重期的预后。 Objective To evaluate the prognosis of patients with acute exacerbation of silicosis in the form of APACHE II score quantification of acute physiology and chronic health status. Methods From January 2005 to December 2009, the clinical data of 238 ICU patients admitted to our hospital with acute exacerbation of silicosis and respiratory failure were enrolled in this study. The APACHEⅡscores of all patients were evaluated. Results APACHE Ⅱ ≤ 10 group, no deaths; 11 to 19 group mortality was 25.00%; 20-29 mortality was 68.18%; ≥ 30 group mortality was 92.86%. Conclusion The APACHEⅡscore can be used to predict the prognosis of ICU silicosis patients during acute exacerbation.