患儿 男,3岁,因膝踝关节肿大,手指足趾末端粗大就诊,患儿系第一胎足月顺产,母乳喂养,8个月出牙,10个月会坐,1岁能走,1.5岁会叫爸妈,生后4月时其母发现指趾末端粗大,至2岁时仍前囟宽大,颅缝不闭,颅骨软,且伴多汗,枕骨两侧有对称性凹陷区,各约2×2cm,按佝偻病治疗无效,后发现膝、踝关节肿大后, Pediatric male, 3 years old, due to knee ankle enlargement, coarse finger toe end of the treatment, the first full-term fetus in children with birth, breastfeeding, teething for 8 months, 10 months will sit, 1-year-old to go , 1.5-year-old will be called parents, after the birth of his mother found in April when the toe end of the coarse, to 2 years old before the fontanelle, cranial sealant, skull soft, and accompanied by sweat, both sides of the occipital symmetry depression District, each about 2 × 2cm, according to rickets treatment ineffective, found that after knee and ankle swelling,