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目的观察米格列醇联合二甲双胍治疗2型糖尿病的临床效果。方法选取医院收治的2型糖尿病患者124例,随机分为对照组和观察组,每组62例。对照组给予二甲双胍治疗,观察组在此基础上联合米格列醇治疗。观察2组治疗前后糖化血红蛋白(Hb A1c)、血清胰高血糖素(PG)及氧化应激因子[丙二醇(MDA)、谷胱甘肽过氧化物酶(GSH-Px)]水平,并统计2组临床治疗效果。结果治疗前,2组Hb A1c、PG及MDA、GSH-Px水平差异无统计学意义(P>0.05);经治疗,观察组Hb A1c、PG、MDA低于对照组,GSH-Px高于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率为98.39%,高于对照组的87.10%(P<0.05)。结论 2型糖尿病患者采用米格列醇联合二甲双胍治疗,可有效降低患者Hb A1c、PG水平,减轻氧化应激反应,临床效果显著。
Objective To observe the clinical effect of miglitol combined with metformin in the treatment of type 2 diabetes mellitus. Methods Totally 124 type 2 diabetic patients admitted to hospital were randomly divided into control group and observation group, with 62 cases in each group. The control group was treated with metformin, and the observation group was treated with miglitol on the basis of this. The levels of Hb A1c, PG and GSH-Px in the two groups were observed before and after treatment, and the levels of Hb A1c, GSH-Px, Group clinical treatment effect. Results Before treatment, the levels of Hb A1c, PG, MDA and GSH-Px in two groups had no significant difference (P> 0.05). After treatment, Hb A1c, PG and MDA in the observation group were lower than those in the control group Group, the difference was statistically significant (P <0.05). The total effective rate of observation group was 98.39%, higher than 87.10% of control group (P <0.05). Conclusions Patients with type 2 diabetes treated with miglitol and metformin can effectively reduce the levels of Hb A1c and PG, and reduce the oxidative stress response. The clinical effect is significant.