雌激素是促进前列腺增殖和肿瘤发生的重要因素。本世纪30年代,Parkes 和 Zuckerman就发现给予雌激素能造成动物前列腺的显著增生。Grayhack 于60年代证实雄性大鼠阉割后,给予雌激素和睾酮治疗,前列腺增生的速度超过单纯给睾酮的大鼠。1976年,Walsh和 Wilson 首次用雌二醇和3α,17β-雄烷二醇成功地诱导了犬前列腺的增殖。近年来的研究还发现,下丘脑、垂体、睾丸和前列腺组织都有雌激素受体,提示雌激素可能在不同水 Estrogen is an important factor in promoting prostate proliferation and tumorigenesis. In the 1930s, Parkes and Zuckerman found that estrogen can cause significant prostate hyperplasia in animals. After castration in the 1960s, Grayhack demonstrated that estrogen and testosterone were given to male rats, with prostate hyperplasia more rapidly than testosterone alone. In 1976, Walsh and Wilson successfully induced canine prostate proliferation with estradiol and 3α, 17β-androstanediol for the first time. In recent years, the study also found that the hypothalamus, pituitary, testis and prostate tissue have estrogen receptors, suggesting that estrogen may be in different water