克山病心肌的主要病理改变是灶状乃至带状分布的变性坏死,在电镜下多可见心肌线粒体肿胀、变形、消失乃至增生等膜系统的改变。同时通过组织化学及生物化学检查看到病死患者心肌线粒体内膜膜结合酶如琥珀酸脱氢酶,细胞色素氧化酶等呼吸 Keshan disease myocardial pathological changes are focal or even zonal distribution of degeneration and necrosis, under the electron microscope can be seen more myocardial mitochondria swelling, deformation, disappearance and even hyperplasia and other membrane system changes. At the same time through histochemical and biochemical examination of patients with myocardial necrosis seen mitochondrial membrane-bound enzymes such as succinate dehydrogenase, cytochrome oxidase and other respiratory