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目的探讨小儿重症暴发性病毒性心肌炎采用甘草酸二胺注射液治疗的疗效及对炎症因子水平、肌酸激酶同工酶(CK-MB)和肌钙蛋白的影响。方法选取2014年6月至2016年6月收治的重症暴发性病毒性心肌炎患儿64例,随机分为观察组和对照组,各32例。两组均行基础治疗,在此基础上对照组采用地塞米松静脉滴注治疗,观察组采用甘草酸二胺注射液治疗,对比两组临床疗效、治疗前后炎症因子水平、CK-MB和肌钙蛋白变化情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(96.88%vs 75.00%,P<0.05);两组治疗后肿瘤坏死因子α(TNF-α)、白介素(IL)-6、IL-8、CK-MB、肌钙蛋白I(c Tn I)、肌钙蛋白T(c Tn T)水平均低于治疗前,差异有统计学意义(P均<0.05);观察组治疗后TNF-α、IL-6、IL-8、CK-MB、c Tn I、c Tn T水平均低于对照组,差异有统计学意义(P<0.05,P<0.01)。结论小儿重症暴发性病毒性心肌炎采用甘草酸二胺注射液治疗可明显提高临床疗效,减轻炎症因子水平,降低心肌酶和肌钙蛋白水平,改善临床症状。
Objective To investigate the effects of glycyrrhizic acid diamine injection in children with severe fulminant viral myocarditis and its effects on the levels of inflammatory cytokines, creatine kinase (CK-MB) and troponin. Methods Sixty-four children with severe fulminant viral myocarditis admitted from June 2014 to June 2016 were randomly divided into observation group and control group, with 32 cases in each group. On the basis of this, the control group was treated with intravenous drip of dexamethasone. The observation group was treated with glycyrrhizic acid diamine injection. The clinical curative effect was compared between the two groups. The levels of inflammatory cytokines, CK-MB and muscle Changes in calmodulin. Results The total effective rate of observation group was significantly higher than that of control group (96.88% vs 75.00%, P <0.05). After treatment, the levels of tumor necrosis factor-α, interleukin- The levels of IL-8, CK-MB, cTn I and cTn T were all lower than those before treatment (all P <0.05). After the treatment, The levels of TNF-α, IL-6, IL-8, CK-MB, cTn I and cTn T were lower than those of the control group (P <0.05, P <0.01). Conclusion Severe fulminant viral myocarditis in children with glycyrrhizic acid diamine injection can significantly improve the clinical efficacy, reduce the level of inflammatory cytokines, reduce myocardial enzymes and troponin levels and improve clinical symptoms.