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目的:了解福州市健康儿童口咽部流感嗜血杆菌(haemophilus influenzae,Hi)带菌情况及菌型特点,提供Hi感染的临床防治依据。方法:选择幼儿园健康日托儿童603名,进行口咽部Hi携带率四季监测,Hi分离株进一步作血清学分型及生物学分型。结果:健康日托儿童口咽部Hi携带率以冬季最高(36.7%),秋季次之(18.0%),春季(10.9%)和夏季(12.4%)相近。Hi分离株血清型秋季以Hib携带率最高(6.9%),冬季以不可分型Hi(NTHi)为主,携带率占17.1%,Hib携带率5.4%,秋、冬季其它各血清型携带率较低。Hi分离株生物型在秋、春、夏季分布较为一致,以生物Ⅶ、Ⅶ型占优势;冬季生物Ⅶ、Ⅶ型明显减少。结论:健康儿童口咽部Hi定殖菌携带率及菌型有季节变迁现象.以冬、秋季Hi携带率较高。提示,在重视Hib结合菌苗接种的同时。应加强Hi新型菌苗的研究。
Objective: To understand the characteristics of fungal infection of haemophilus influenzae (Hi) in the oropharynx of healthy children in Fuzhou and to provide the basis for prevention and control of Hi infection. Methods: 603 kindergartens healthy day-care children were selected to carry out four-season monitoring of oropharyngeal Hi carrying rate. Hi isolates were further screened for serological typing and biological typing. Results: The Hi carrying rate of oropharynx in healthy day-care children was highest in winter (36.7%), autumn (18.0%), spring (10.9%) and summer (12.4%). The isolates of Hi isolates had the highest Hib carrying rate (6.9%) in autumn, Hi (NTHi) mostly in winter, carrying rate of 17.1% and Hib carrying rate of 5.4%, and the carriage rates of other strains in autumn and winter were lower . The biotypes of Hi isolates were more consistent in the autumn, spring and summer, with biological Ⅶ and Ⅶ dominant, while the biological Ⅶ and Ⅶ were significantly reduced in winter. Conclusion: The rate of colonization of Hi colonization and the seasonal variation of the colonies in healthy children are higher than those in other regions. Tip, in the emphasis on Hib conjugate vaccine inoculation at the same time. Should be strengthened Hi new vaccine research.