论文部分内容阅读
选用老年大鼠进行阿霉素攻击，观察其气血变化规律，以期建立符合中医气虚血瘀证的慢性伤口模型。实验结果显示：阿霉素攻击的老年大鼠一般状况表现为倦怠、腹泻，体重减轻，白细胞下降，符合气虚的辨证规律。同时大鼠血浆ＴＸＢ２从实验前３５４．１０±１６０．７５ｐｇ／ｍｌ在攻击后第３、７天分别升至６３８．１６±１７５．３３ｐｇ／ｍｌ（Ｐ＜０．０５）和６９７．７６±５５６．６３ｐｇ／ｍｌ（Ｐ＜０．０５）；而血浆６－酮－ＰＧＦ１α则由实验前的７８．３７±２６．８１ｐｇ／ｍｌ分别降至６０．１２±１８．２７ｐｇ／ｍｌ和６４．１９±３５．２２ｐｇ／ｍｌ，分别Ｐ＜０．０５，Ｐ＜０．０５；ＴＸＢ２／６－酮－ＰＧＦ１α的比值变化更明显，阿霉素攻击第３、７天分别升高至１０．６９±５．９８和８．４９±４．１８，与同期生理盐水对照组４．１４±１．８７，３．８０±１．５５相比，分别Ｐ＜０．０５，Ｐ＜０．０５，结果符合中医的血瘀证指标；同时阿霉素攻击大鼠的伤口愈合时间也由对照组的１７．１８±１．７２天延迟至１９．８±３．１９（Ｐ＜０．０５）；伤口的愈合强度明显下降由对照组的８．６８±１．５６Ｋｇ／ｃｍ２降至６．３６±１．３６Ｋｇ／ｃｍ２（Ｐ＜０．０?
Adopt adriamycin to attack the aged rats and observe the changing rules of qi and blood, in order to establish a chronic wound model which accords with the Qi-deficiency and blood stasis syndrome of Chinese medicine. The experimental results showed that the general condition of adriamycin-challenged senile rats manifested as burnout, diarrhea, weight loss and leukopenia, which accorded with syndrome differentiation and deficiency syndrome. At the same time, the level of TXB2 in rat plasma increased from 354.10 ± 160.75pg / ml before the experiment to 638.16 ± 175.33pg / ml (P <0.05) and 697.76 ± 556 (P <0.05), while the plasma 6-keto-PGF1α decreased from 78.37 ± 26.81pg / ml before the experiment to 60.12 ± 18.27pg / ml and 64.19 ± 35.22pg / ml, respectively, P <0.05, P <0.05; the ratio of TXB2 / 6-keto-PGF1α changed more obviously, the levels of doxorubicin increased to 10.69 ± 5 .98 and 8.49 ± 4.18 respectively, compared with 4.14 ± 1.87 and 3.80 ± 1.55 in normal saline control group, P <0.05 and P <0.05 respectively Chinese medicine blood stasis index; at the same time doxorubicin attack in rats wound healing time by the control group 17.18 ± 1. 2 days delayed to 19.8 ± 3.19 (P <0.05); the wound healing intensity decreased significantly from 8.68 ± 1.56 Kg / cm2 in the control group to 6.36 ± 1.36 Kg / cm2 ( P <0.0?